Vishal Gohil
professor
Biochemistry and Biophysics
Texas A&M University
United States of America
Biography
Despite the fundamental role of the mitochondrion in cellular energy production and its involvement in numerous human diseases, we still do not know the function of nearly 20% of the known mitochondrial proteins. My laboratory applies genomic, genetic, and biochemical tools to uncover the role of these uncharacterized proteins in the mitochondrial respiratory chain (MRC) biogenesis. MRC is the main site of cellular respiration and energy production and since the core components of the MRC are evolutionarily conserved, we reason that the assembly factors required to build the MRC should also be conserved. Therefore, we utilize multiple models systems, including yeast, zebrafish, and human cell lines, to determine the role of these conserved, uncharacterized mitochondrial proteins in bioenergetics, organismal development, and human disease pathogenesis.
Research Interest
Mitochondrial Respiratory Chain Biogenesis
Publications
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Ghosh, A, Pratt, AT, Soma, S, Theriault, SG, Griffin, AT, Trivedi, PP et al.. Mitochondrial disease genes COA6, COX6B and SCO2 have overlapping roles in COX2 biogenesis. Hum. Mol. Genet. 2016;25 (4):660-71. doi: 10.1093/hmg/ddv503. PubMed PMID:26669719. PubMed Central PMC4743686.
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Tomar, D, Dong, Z, Shanmughapriya, S, Koch, DA, Thomas, T, Hoffman, NE et al.. MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics. Cell Rep. 2016;15 (8):1673-85. doi: 10.1016/j.celrep.2016.04.050. PubMed PMID:27184846. PubMed Central PMC4880542
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Baker, CD, Basu Ball, W, Pryce, EN, Gohil, VM. Specific requirements of nonbilayer phospholipids in mitochondrial respiratory chain function and formation. Mol. Biol. Cell. 2016;27 (14):2161-71. doi: 10.1091/mbc.E15-12-0865. PubMed PMID:27226479. PubMed Central PMC4945136.
