Allan M. Weissman
Laboratory of Protein Dynamics and Signaling
The Center for Cancer Research
United States of America
Biography
Dr. Allan Weissman received his B.S. from Stony Brook University and his M.D. from Albert Einstein College of Medicine in 1981. After a residency in Internal Medicine at Washington University, he came to NIH where he was a post-doctoral fellow in NICHD. In 1989, he joined the NCI as an independent investigator. In 2001 he was appointed Laboratory Chief and is currently the Chief of the Laboratory of Protein Dynamics and Signaling.
Research Interest
Cancer Biology, Cell Biology, Immunology, Molecular Biology and Biochemistry, Structural Biology
Publications
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Differential regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and Insig-1 by enzymes of the ubiquitin-proteasome system. Tsai YC, Leichner GS, Pearce MMP, Wilson GL, Wojcikiewicz RJH, Roitelman J, and Weissman AM. Mol. Biol. Cell. 23: 4484-94, 2012
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A structurally unique E2-binding domain activates ubiquitination by the ERAD E2, Ubc7p, through multiple mechanisms. Metzger MB, Liang Y-H, Das R, Mariano J, Li S, Kostova Z, Byrd RA, Ji X, and Weissman AM. Mol. Cell. 50: 516-27, 2013
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Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. Li S, Liang Y-H, Mariano J, Metzger MB, Stringer DK, Hristova VA, Li J, Randazzo PA, Tsai YC, Ji X and Weissman AM. J Bio. Chem. 290: 30225-39, 2015
