Carl Wu
Laboratory of Biochemistry and Molecular Biology
The Center for Cancer Research
United States of America
Biography
Dr. Wu received his Ph.D. (1979) under Sarah Elgin at Harvard University, where he began studies of chromatin organization at specific genes. As a Junior Fellow at Harvard under Nobel laureate Wally Gilbert, he provided the first evidence that chromatin is remodeled as DNase I hypersensitive sites at cellular gene promoters. After moving to the NCI in 1982, Dr. Wu began investigating the biochemical mechanism of chromatin remodeling. In 1994, his group reported the discovery of the first ATP-dependent chromatin remodeling activity in cell-free extracts, and in the following year, purification and characterization of the responsible enzyme, named NURF. This work has been noted by Nature as a milestone in the field of gene expression over the past 50 years. Dr. Wu is an elected member of the National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences, the Academia Sinica, and the European Molecular Biology Organization.
Research Interest
chromatin architecture
Publications
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Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes. Li X, Wang S, Li Y, Deng C, Steiner LA, Xiao H, Wu C, Bungert J, Gallagher PG, Felsenfeld G, Qiu Y, Huang S. Blood. 118: 1386-94, 2011.
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Fast multicolor 3D imaging using aberration-corrected multifocus microscopy. Abrahamsson S, Chen J, Hajj B, Stallinga S, Katsov AY, Wisniewski J, Mizuguchi G, Soule P, Mueller F, Dugast Darzacq C, Darzacq X, Wu C, Bargmann CI, Agard DA, Dahan M, Gustafsson MG. Nat. Methods. 10: 60-3, 2013.
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Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3. Zhou Z, Feng H, Zhou BR, Ghirlando R, Hu K, Zwolak A, Miller Jenkins LM, Xiao H, Tjandra N, Wu C, Bai Y. Nature. 472: 234-7, 2011.
