Chuan Wu
Experimental Immunology Branch
The Center for Cancer Research
United States of America
Biography
Dr. Wu completed his M.D. studies in China at Shanghai Jiaotong University School of Medicine, and then studied immunology and matrix biology as a graduate student at Muenster University, Germany. His main focus was T cell migration during the central nervous system (CNS) inflammation. He joined Dr. Vijay Kuchroo’s lab in Brigham and Women’s Hospital, Harvard Medical School as a postdoctoral fellow where he studied the molecular regulation of T cell differentiation during inflammation and autoimmunity. In 2017, Dr. Wu started a position as an NIH Stadtman Tenure-Track Investigator at the Experimental Immunology Branch where he studies the cellular and molecular mechanisms of neuro-immune interactions.
Research Interest
Cell Biology, Immunology, Microbiology and Infectious Diseases, Molecular Biology and Biochemistry, Neuroscience
Publications
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Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Murugaiyan G, Xiao S, Lee Y, Rangachari M, Yosef N, and Kuchroo VK. Proc Natl Acad Sci U S A. 110(19): 7802-7, 2013.
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Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Wu C, Thalhamer T, Franca RF, Xiao S, Wang C, Hotta C, Zhu C, Hirashima M, Anderson AC, and Kuchroo VK. Immunity. 41(2): 270-82, 2014.
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The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program. Wu C*, Chen Z, Dardalhon V, Xiao S, Thalhamer T, Liao M, Madi A, Franca RF, Han T, Oukka M, and Kuchroo VK. *Corresponding author. Nature Immunology. 18(3): 344-53, 2017.
