Claudia M. Palena
Immunoregulation Group
The Center for Cancer Research
United States of America
Biography
Dr. Claudia Palena received her Ph.D. degree in Biochemistry from the National University of Rosario, Argentina, in 2000. She subsequently joined the NIH as a Postdoctoral Fellow in the Laboratory of Tumor Immunology and Biology of the National Cancer Institute, and was appointed as a Staff Scientist in 2008 and as a Tenure-Track Investigator in the same laboratory in August 2011. Dr. Palena's current research is focused on the development of novel immunotherapeutic approaches aimed at targeting critical events in tumor progression with the ultimate goal of designing vaccine platforms and combinatorial therapies for the prevention and/or treatment of metastases in human cancer.
Research Interest
Cancer Biology, Clinical Research, Immunology
Publications
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The embryonic transcription factor Brachyury blocks cell cycle progression and mediates tumor resistance to conventional antitumor therapies. Huang B, Cohen JR, Fernando RI, Hamilton DH, Litzinger MT, Hodge JW, Palena C. Cell Death Dis. 4: e682, 2013
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IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. Fernando RI, Castillo MD, Litzinger M, Hamilton DH, Palena C. Cancer Res. 71: 5296-306, 2011
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The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells. Fernando RI, Litzinger M, Trono P, Hamilton DH, Schlom J, Palena C. J. Clin. Invest. 120: 533-44, 2010
