David A. Wink Jr
Molecular Mechanisms Section
The Center for Cancer Research
United States of America
Biography
Dr. David A. Wink received his Ph.D. in chemistry at the University of California, Santa Barbara. Following a postdoctoral fellowship in biochemistry as a National Research Service Award recipient at the Massachusetts Institute of Technology, he joined the Laboratory of Comparative Carcinogenesis at the NCI Frederick Cancer Research and Development Center (FCRDC) as a staff fellow. He then joined the Radiation Biology Branch at the NCI in 1995, where he received tenure in November 1999. He has chaired the Gordon conference on Nitric oxide in Barga Italy in 2009. In 2008 he was nominated as a Fellow of the American Association for the Advancement in Science in Chemistry.
Research Interest
Cancer Biology, Chemical Biology, Immunology, Molecular Biology and Biochemistry, Molecular Pharmacology
Publications
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Soto-Pantoja DR, Ridnour LA, Wink DA, Roberts DD (2013) Blockade of CD47 increases survival of mice exposed to lethal total body irradiation. Sci Rep. 3: 1038.
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Heinrich TA, Dasilva RS, Miranda KM, Switzer CH, Wink DA, et al. (2013) Biological nitric oxide signaling: chemistry and terminology (NO chemical biology and terminology). Br. J. Pharmacol. 169: 1417-29.
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Basudhar D, Bharadwaj G, Cheng RY, Jain S, Shi S, et al. (2013) Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives. J. Med. Chem. 56: 7804-20.
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Heinecke JL, Ridnour LA, Cheng RY, Switzer CH, Lizardo MM, et al. (2014) Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression. Proc. Natl. Acad. Sci. U.S.A. 111: 6323-8.
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Miranda KM, Wink DA (2014) Persulfides and the cellular thiol landscape. Proc. Natl. Acad. Sci. U.S.A. 111: 7505-6.
