David D. Roberts
Laboratory of Pathology
The Center for Cancer Research
United States of America
Biography
Dr. Roberts received his B.S. in Chemistry from the Massachusetts Institute of Technology and his Ph.D. in Biological Chemistry from The University of Michigan. After postdoctoral training at Michigan and in the Laboratory of Biochemical Pharmacology of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), he became a research chemist in the NIDDK and later joined the NCI as chief of the Biochemical Pathology Section. He serves on peer review panels and on the editorial boards of the Journal of Biological Chemistry, PLoS One, Scientific Reports, and Cellular and Molecular Life Sciences. His research interests include tumor cell-matrix interactions, angiogenesis, redox biology, the biochemistry of cell surface carbohydrates, and host-pathogen interactions.
Research Interest
Cancer Biology, Chemical Biology, Immunology, Stem Cell Biology
Publications
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Kaur S, Soto-Pantoja DR, Stein EV, Liu C, Elkahloun AG, et al. (2013) Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors. Sci Rep. 3: 1673.
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Soto-Pantoja DR, Shih HB, Maxhimer JB, Cook KL, Ghosh A, et al. (2014) Thrombospondin-1 and CD47 signaling regulate healing of thermal injury in mice. Matrix Biol. 37: 25-34.
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Kaur S, Singh SP, Elkahloun AG, Wu W, Abu-Asab MS, et al. (2014) CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells. Matrix Biol. 37: 49-59.
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Kaur S, Chang T, Singh SP, Lim L, Mannan P, et al.(2014) CD47 signaling regulates the immunosuppressive activity of VEGF in T cells. J. Immunol. 193: 3914-3924.
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Soto-Pantoja DR, Terabe M, Ghosh A, Ridnour LA, DeGraff WG, et al. (2014) CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy. Cancer Res. 74: 6771-6783.
