Deedee K. Smart
Radiation Oncology Branch
The Center for Cancer Research
United States of America
Biography
Dr. Smart completed her medical and graduate education in 2003 at the Medical College of Georgia, followed by a year as a Cancer Research Training Award (CRTA) post-doctoral fellow at the NCI Radiation Oncology Branch under the mentorship of Dr. David R. Gius. She then completed an internship in Internal Medicine at Thomas Jefferson University Hospital in Philadelphia, Pennsylvania, followed by Radiation Oncology residency at the National Capital Consortium Hospitals/NCI. After completing her training in 2009, she became an Assistant Clinical Investigator in the NCI's Radiation Oncology Branch with a clinical focus on CNS primary tumors and brain metastases and their treatment with stereotactic radiosurgery, as well as late neurocognitive sequelae of radiation. Her scientific pursuits focus on CNS sirtuins in radiation-induced vascular permeability and neurodegeneration, as well as targeted therapies and radiation enhancing agents for the treatment of cerebral metastases.
Research Interest
Cancer Biology, Cell Biology, Chromosome Biology, Clinical Research, Neuroscience
Publications
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Axillary sentinel lymph node biopsy after mastectomy: a case report. Vicente DA, Henry LR, Hahm G, Soballe PW, Smart D. World J Surg Oncol. 8: 59, 2010.
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Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis. Gril B, Palmieri D, Qian Y, Smart D, Ileva L, Liewehr DJ, Steinberg SM, Steeg PS. Clin. Cancer Res. 17: 142-53, 2011.
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SIRT2 interacts with ß-catenin to inhibit Wnt signaling output in response to radiation-induced stress. Nguyen P, Lee S, Lorang-Leins D, Trepel J, Smart DD. Mol. Cancer Res. 12: 1244-53, 2014
