Haobin Chen
Thoracic and Gastrointestinal Oncology Branch
The Center for Cancer Research
United States of America
Biography
Dr. Chen received his M.D. and M.S. from Shanghai Medical University in China, and his Ph.D. degree from New York University (NYU). He was a research assistant professor at NYU for 4 years, and then completed an internal medicine residency at the Kingsbrook Jewish Medical Center in Brooklyn, NY. He joined the NCI Medical Oncology Branch as a clinical fellow in 2013. He is currently an assistant clinical investigator in the Thoracic and Gastrointestinal Oncology Branch.
Research Interest
Cancer Biology, Chromosome Biology, Clinical Research, Genetics and Genomics, Molecular Biology and Biochemistry
Publications
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Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing. Chen H, Ke Q, Kluz T, Yan Y, Costa M. Mol Cell Biol. 26: 3728-3737, 2006.
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Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers. Chen H, Giri N, Zhang R, et al. J Biol Chem. 285: 7374-7383, 2010.
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Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Chen H, Zhang R, Kluz T, Costa M. Carcinogenesis. 31: 2136-2144, 2010.
