Jack F. Shern
Pediatric Oncology Branch
The Center for Cancer Research
United States of America
Biography
After completing undergraduate studies at The University of Notre Dame, South Bend, Indiana, Dr. John 'Jack' Shern received his M.D. from the Medical College of Georgia in 2007. This was followed by his pediatric internship and residency training at The University of Chicago Comer Children's hospital, which he completed in 2010. He then joined the combined Pediatric Hematology and Oncology Fellowship training program at the National Cancer Institute, Pediatric Oncology Branch (POB) and Johns Hopkins University. In his fellowship, Dr. Shern worked under the mentorship of Dr. Javed Khan in the Center for Cancer Research Genetics Branch to use next generation sequencing to profile the somatic changes which drive multiple pediatric solid tumors. Dr. Shern currently serves as an Assistant Clinical Investigator in the POB.
Research Interest
Cancer Biology, Cell Biology, Computational Biology, Genetics and Genomics, Molecular Biology and Biochemistry
Publications
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Pediatric Rhabdomyosarcoma. Shern JF, Yohe ME, Khan J Critical Rev in Oncogenesis. 20: 227-243, 2015.
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Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. Shern JF, Chen L, Chmielecki J, Wei JS, Patidar R, Rosenberg M, Ambrogio L, Auclair D, Wang J, Song YK, Tolman C, Hurd L, Liao H, Zhang S, Bogen D, Brohl AS, Sindiri S, Catchpoole D, Badgett T, Getz G, Mora J, Anderson JR, Skapek SX, Barr FG, Meyerson M, Hawkins DS, Khan J Cancer Discovery. 4: 216-231, 2014.
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4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Long AH, Haso WM, Shern JF, Wanhainen KM, Murgai M, Ingaramo M, Smith JP, Walker AJ, Kohler ME, Venkateshwara VR, Kaplan RN, Patterson GH, Fry TJ, Orentas RJ, Mackall CL Nature Med.. 21: 581-590, 2015.
