James B. Mitchell
Radiation Biology Branch
The Center for Cancer Research
United States of America
Biography
Dr. Mitchell received his Ph.D. from Colorado State University in cellular radiation biology in 1978. He came to the NIH and the Radiation Oncology Branch of the NCI in 1979 and became an independent investigator in 1984. He served as chief of the Radiobiology Section and later as deputy branch chief of the Radiation Oncology Branch. In 1993, he was named chief of the Radiation Biology Branch. In 2009, the American Society of Therapeutic Radiation Oncology named Dr. Mitchell an ASTRO Fellow and in 2010 he received the Failla Award from the Radiation Research Society.
Research Interest
Cancer Biology, Cell Biology, Molecular Biology and Biochemistry, Molecular Pharmacology
Publications
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In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762. Mitchell JB, Choudhuri R, Fabre K, Sowers AL, Citrin D, Zabludoff SD, Cook JA. Clin. Cancer Res. 16: 2076-84, 2010.
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A novel nitroxide is an effective brain redox imaging contrast agent and in vivo radioprotector. Davis RM, Sowers AL, Degraff W, Bernardo M, Thetford A, Krishna MC, Mitchell JB. Free Radic. Biol. Med. 51: 780-90, 2011
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The antioxidant Tempol reduces carcinogenesis and enhances survival in mice when administered after non-lethal total body radiation. Mitchell JB, Anver MR, Sowers A, Rosenberg PS, Figueroa M, Thetford A, Krishna MC, Albert PS, Cook JA. Cancer Res. 72: 4846-55, 2012
