James C. Yang
Surgery Branch
The Center for Cancer Research
United States of America
Biography
Dr. Yang graduated from the Massachusetts Institute of Technology with a B.S. in biology. He then completed his M.D. and surgical internship and residency at the University of California, San Diego. In 1984, he came to the Surgery Branch, NCI, as a medical staff fellow. He subsequently became a senior staff fellow, then a senior investigator in 1987. He has been involved in studies of the immune response to tumor-associated antigens and has been a principal investigator of clinical trials in renal cell carcinoma and soft tissue sarcoma.
Research Interest
Clinical Research, Immunology
Publications
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PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors. Gros A, Robbins PF, Yao X, Li YF, Turcotte S, Tran E, Wunderlich JR, Mixon A, Farid S, Dudley ME, Hanada K, Almeida JR, Darko S, Douek DC, Yang JC, Rosenberg SA. J. Clin. Invest. 124: 2246-59, 2014
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Melanoma: Why is sentinel lymph node biopsy "standard of care" for melanoma?. Yang JC, Sherry RM, Rosenberg SA. Nat Rev Clin Oncol. 11: 245-6, 2014.
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Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Tran E, Turcotte S, Gros A, Robbins PF, Lu YC, Dudley ME, Wunderlich JR, Somerville RP, Hogan K, Hinrichs CS, Parkhurst MR, Yang JC, Rosenberg SA. Science. 344: 641-5, 2014
