Jayne M. Stommel
Radiation Oncology Branch
The Center for Cancer Research
United States of America
Biography
Dr. Stommel received her B.S. Magna cum Laude with College Honors in Cell and Molecular Biology from the University of Washington in Seattle. She received a Ph.D. from the University of California, San Diego with Dr. Geoffrey Wahl at The Salk Institute for Biological Studies in La Jolla. Her Ph.D. thesis work examined the molecular interactions of p53 and MDM2 and was funded by an NSF Graduate Research Fellowship. She then trained as a post-doc under Dr. Ronald DePinho at the Dana-Farber Cancer Institute/Harvard Medical School in Boston, focusing on Receptor Tyrosine Kinase signaling in Glioblastoma Multiforme and Colorectal Cancer. Her post-doctoral work was funded by an American Brain Tumor Association Fellowship, a Ruth L. Kirschstein National Research Service Award (NRSA), a DFCI/Harvard Cancer Center Gastrointestinal SPORE Career Development Award, and an NIH Pathway to Independence (PI) Award (K99/R00). Dr. Stommel joined the NCI as a Tenure-Track Investigator in September 2010.
Research Interest
Cancer Biology, Cell Biology, Molecular Biology and Biochemistry, Molecular Pharmacology
Publications
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p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA. Nature. 455: 1129-33, 2008.
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Malignant astrocytic glioma: genetics, biology, and paths to treatment. Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK. Genes Dev. 21: 2683-710, 2007.
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Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA. Science. 318: 287-90, 2007.
