Jeffrey N. Strathern
RNA Biology Laboratory
The Center for Cancer Research
United States of America
Biography
Dr. Strathern obtained his Ph.D. from the Molecular Biology Institute at the University of Oregon in 1977, then moved to Cold Spring Harbor Laboratory where he became a senior staff member with the Yeast Genetics Laboratory. In 1984, he joined the ABL-Basic Research Program at the NCI's Frederick Cancer Research Development Center (now NCI-Frederick). His research remains centered on aspects of gene regulation, transcription fidelity, and genetic recombination as revealed by studies in yeast. In 1999, Dr. Strathern joined the Division of Basic Sciences, NCI. In March 2001, the Division of Basic Sciences merged with the Division of Clinical Sciences to form the NCI Center for Cancer Research. In addition to his roles as Chief of GRCBL and Head of the Gene Regulation and Recombination Section, Dr. Strathern was a Deputy Director for the NCI-Center for Cancer Research. He is now an emeritus member of the RNA Biology Laboratory.
Research Interest
Chromosome Biology, Genetics and Genomics, Molecular Biology and Biochemistry
Publications
-
The fidelity of transcription: RPB1 (RPO21) mutations that increase transcriptional slippage in S. cerevisiae. Strathern J, Malagon F, Irvin J, Gotte D, Shafer B, Kireeva M, Lubkowska L, Jin DJ, Kashlev M. J. Biol. Chem. 288: 2689-99, 2013.
-
Isolation and characterization of RNA polymerase rpoB mutations that alter transcription slippage during elongation in Escherichia coli. Zhou YN, Lubkowska L, Hui M, Court C, Chen S, Court DL, Strathern J, Jin DJ, Kashlev M. J. Biol. Chem. 288: 2700-10, 2013.
-
Intrinsic translocation barrier as an initial step in pausing by RNA polymerase II. Imashimizu M, Kireeva ML, Lubkowska L, Gotte D, Parks AR, Strathern JN, Kashlev M. J. Mol. Biol. 425: 697-712, 2013
