Joseph J. Barchi Jr.
Structural Glycoconjugate Chemistry and NMR Group
The Center for Cancer Research
United States of America
Biography
Dr. Barchi received his Ph.D. in Organic Chemistry from the University of Hawaii with Richard E. Moore and did 2 years of postdoctoral work at Duke University with Bert Fraser-Reid. He then joined the NCI as a staff fellow in 1988, was promoted to staff scientist and then to senior scientist in 2002. His main research interests are in synthetic medicinal chemistry as it relates to carbohydrate-based drug design, and the high-resolution structural analysis of sugars, glycopeptides and small molecule drug candidates by NMR spectroscopy.
Research Interest
Chemical Biology, Immunology, Structural Biology
Publications
-
Glinskii OV, Li F, Wilson LS, Barnes S, Rittenhouse-Olson K, et al. (2014) Endothelial Integrin α3β1 Stabilizes Carbohydrate-Mediated Tumor/Endothelial Cell Adhesion and Induces Major Signaling Pathways in Endothelial Cells. Oncotarget. 5: 1382-1389.
-
Luo M, Velikovsky CA, Yang X, Siddiqui MA, Hong X, et al. (2013) Recognition of the Thomsen-Friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor. J. Biol. Chem. 288: Am. Society for Biochemistry and Molecular Biology 23597-23606.
-
Barchi Jr JJ (2013) Mucin-type glycopeptide structure in solution: Past, present, and future. Biopolymers. 99: John Wiley and American Peptide Society 713-723.
