Lawrence E. Samelson
Laboratory of Cellular and Molecular Biology
The Center for Cancer Research
United States of America
Biography
Dr. Samelson received his M.D. degree from Yale University in 1977. Following training in internal medicine at the University of Chicago, he carried out postdoctoral research at the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases. He joined the Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development in 1985, became senior investigator in 1988, and chief of the Section on Lymphocyte Signaling and deputy branch chief in 1995. He became chief of the Laboratory of Cellular and Molecular Biology, NCI, in 1999.
Research Interest
Cancer Biology, Cell Biology, Immunology, Molecular Biology and Biochemistry
Publications
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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. Bunnell SC, Hong DI, Kardon JR, Yamazaki T, McGlade CJ, Barr VA, Samelson LE. J. Cell. Biol. 158: 1263-1275, 2002
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Absence of both Sos-1 and Sos-2 in peripheral CD4+ T cells leads to PI3K pathway activation and defects in migration. Guittard, G, Kortum, RL, Balagopalan, L, Cuburu, N, Nguyen P, Sommers, CL, Samelson, LE European Journal of Immunology. 45(8): 2389-95, 2015.
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The Linker for Activation of T cells (LAT) signaling hub: from signaling complexes to micro clusters. Balagopalan, L., Kortum, RL, Coussens, NP, Barr, VA, Samelson, LE J Biol Chem. 290(44): 26422-9, 2015.
