Lixin Fan
Structural Biophysics Laboratory
The Center for Cancer Research
United States of America
Biography
Dr. Lixin Fan obtained her Ph.D. in physics and mathematics from the Joint Institute for Nuclear Research (Dubna, Moscow region, Russia) and the Institute of Protein Research, Russian Academy of Sciences (Puschino, Moscow region, Russia) where she used small-angle neutron and X-ray scattering (SANS and SAXS) to study the structure of the 30S ribosomal subunit from Thermus thermophilus. From 2000-2002, as a Postdoctoral Fellow at the Intense Pulsed Neutron Source Division of Argonne National Laboratory (ANL), she studied the block copolymer self-assembly and phase transition using SAXS and SANS techniques. From 2002-2007, she worked at the Advanced Photon Source Division of ANL where she served the user community and developed a novel technique known as “fluctuation X-ray microscopy" based on coherent X-ray scattering and X-ray scanning probe imaging techniques and applied this technique for studying medium-range order in disordered materials. Before she joined the CCR SAXS Core Facility, Dr. Fan worked as an applications scientist at Rigaku Innovative Technologies, where she trained researchers worldwide in using the SAXS technique, developed in-house SAXS/GISAXS instrument and applications, characterized a wide range of nanomaterials using SAXS/WAXS, USAXS and GISAXS techniques. As a SAXS expert and a member of the U.S. delegation, she contributed to ISO standard ISO/FDIS 17867 «Particle Size Analysis – Small-Angle X-Ray Scattering». Dr. Fan joined the CCR SAXS Core Facility in 2014, where she serves the NCI and NIH intramural and extramural user community and conducts research focusing on the structural characterization of biomacromolecules and their complexes.
Research Interest
Structural Biology
Publications
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Determination of deuterium incorporation into RNA and protein components of the E.coli ribosome at biosynthetic deuteration by small-angle neutron scattering. Fan L, Zgurskaya EI, and Serdyuk IN. J Appl Crystallogr. 30: 59, 1997.
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Fluctuation X-ray microscopy: a novel approach for structural study of disordered materials. Fan F, Paterson D, McNulty I, Treacy MMJ, and Gibson JM. J Microsc. 225: 41, 2007.
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New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins. Zhang Q, Fan L, Hou F, Dong A, Wang YX, and Tong Y. Sci Rep. 5: 15660, 2015.
