Marielle E. Yohe
Pediatric Oncology Branch
The Center for Cancer Research
United States of America
Biography
After completing her undergraduate work at Wellesley College, Dr. Yohe received her M.D. and Ph.D from the University of North Carolina at Chapel Hill. She did her graduate work in the laboratory of Dr. John Sondek in the Department of Pharmacology. In this work, she addressed how truncation of Dbl-family Rho guanine nucleotide exchange factors leads to their aberrant activation. She completed her internship and residency in pediatrics at Connecticut Children's Medical Center in Hartford, CT, followed by fellowship training at the combined National Cancer Institute - Johns Hopkins University Hematology/Oncology program. She did her postdoctoral work in the laboratory of Dr. Javed Khan in the Genetics Branch of the CCR. Dr. Yohe is board certified in General Pediatrics (2013) and Pediatric Hematology/Oncology (2017). She is the recipient of an Alex's Lemonade Stand Foundation Young Investigator Award.
Research Interest
Cancer Biology, Clinical Research, Genetics and Genomics, Molecular Biology and Biochemistry, Molecular Pharmacology
Publications
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Clonality and evolutionary history of rhabdomyosarcoma. Chen L, Shern JF, Wei JS, Yohe ME, Song YK, Hurd L, Liao H, Catchpoole D, Skapek SX, Barr FG, Hawkins DS, and Khan J. PLoS Genetics. 11: e1005075, 2015.
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Pediatric Rhabdomyosarcoma. Shern JF, Yohe ME and Khan J. Critical Reviews in Oncogenesis. 20: 227-243, 2015.
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PAX3-FOXO1 establishes myogenic super enhancers and confers BET bromodomain vulnerability. Gryder BE, Yohe ME, Chou H-C, Zhang X, Song Y, Marques J, Schaefer B, Sen N, Patidar R, Wen X, Wei J, Guha R, Ferrer M, Lal-Nag M, Andresson T, Shern JF, Zhao K, Thomas CJ, and Khan J. Cancer Discovery. 7: 884-899, 2017.
