Martin J. Schnermann
Chemical Biology Laboratory
The Center for Cancer Research
United States of America
Biography
Dr. Schnermann attended Colby College and graduated in 2002 with degrees in Chemistry and Physics. At Colby, he worked with Prof. Dasan Thamattoor in the areas of physical organic chemistry and photochemistry. After a year at Pfizer Research and Development (Groton, CT) as an associate in the medicinal chemistry division, he moved to the Scripps Research Institute. During his graduate studies, he performed research on the total synthesis and biological evaluation of anticancer natural products with Prof. Dale Boger and obtained a Ph.D. in 2008. He then completed an NIH-postdoctoral fellowship with Prof. Larry Overman at the University of California, Irvine. At Irvine, he developed light-mediated reactions to enable the synthesis of complex natural products. In addition, working with Prof. Christine Suetterlin, he pursued chemical biology and imaging studies of organelle specific probes. In 2012, Dr. Schnermann joined the NCI where his research focuses on the synthesis and development of new small-molecule imaging agents for cancer treatment and diagnosis.
Research Interest
Cancer Biology, Chemical Biology, Molecular Pharmacology
Publications
-
Near-infrared uncaging or photosensitizing dictated by oxygen tension. Anderson ED, Gorka AP and Schnermann MJ Nature Communications. 7: 2016.
-
Near-IR Light-Mediated Cleavage of Antibody-Drug Conjugates Using Cyanine Photocages. Nani RR, Gorka AP, Nagaya T, Kobayashi H, Schnermann MJ Angew. Chem. Int. Ed. Engl. 54(46): 13635-8, 2015.
-
A near-IR uncaging strategy based on cyanine photochemistry. Gorka AP, Nani RR, Zhu J, Mackem S, and Schnermann MJ J Am Chem Soc. 136: 14153-9, 2014.
