Maureen P. Martin
Cancer and Inflammation Program
The Center for Cancer Research
United States of America
Biography
Dr. Martin obtained her M.D. at the University of the West Indies, Jamaica in 1982 and completed a residency in pathology in 1989. She was a visiting research fellow in the Laboratory of Viral Carcinogenesis, NCI at Frederick from 1990-1995. Dr. Martin is currently a senior scientist (Leidos Biomedical Research, Inc.) in the HLA Immunogenetics Section of Dr. Mary Carrington, Laboratory of Experimental Immunology, Cancer and Inflammation Program. Her research interests involve studies of host genetic effects on complex human diseases including infectious diseases, autoimmune diseases and cancer. Her focus is on genes known to participate in innate and acquired immunity, primarily the killer Immunoglobulin-like receptor (KIR) genes and related loci.
Research Interest
Determine the genetic effects of HLA and KIR variants on disease. Given the importance of KIR-mediated regulation of natural killer (NK) cell activity, their specificity for HLA class I allotypes, and their extensive genomic diversity, our efforts are geared towards characterizing the effects of KIR gene variation in resistance and susceptibility to diseases.
Publications
-
Recombinant structures expand and contract inter and intragenic diversification at the KIR locus. Pyo CW, Wang R, Vu Q, Cereb N, Yang SY, Duh FM, Wolinsky S, Martin MP, Carrington M, Geraghty DE. BMC Genomics. 14: 89, 2013.
-
Immunogenetics of HIV disease. Martin MP, Carrington M. Immunol Rev. 254: 245-64, 2013.
-
Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease. Salie M, van der Merwe L, Möller M, Daya M, van der Spuy GD, van Helden PD, Martin MP, Gao XJ, Warren RM, Carrington M, Hoal EG. J Infect Dis. 209: 216-23, 2014.
