Peter M. Blumberg
Laboratory of Cancer Biology and Genetics
The Center for Cancer Research
United States of America
Biography
Dr. Blumberg received both his A.B., summa cum laude, and his Ph.D. from the Department of Biochemistry and Molecular Biology, Harvard University. He was Helen Hay Whitney fellow at the Cancer Center, Massachusetts Institute of Technology, and was assistant and associate professor of pharmacology at Harvard Medical School. Since 1981, Dr. Blumberg has been chief of the Molecular Mechanisms of Tumor Promotion Section.
Research Interest
Cancer Biology, Cell Biology, Molecular Pharmacology, Neuroscience
Publications
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Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function. Keck GE, Kraft MB, Truong AP, Li W, Sanchez CC, Kedei N, Lewin NE, Blumberg PM. J. Am. Chem. Soc. 130: 6660-1, 2008.
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RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma. Yang D, Tao J, Li L, Kedei N, Tóth ZE, Czap A, Velasquez JF, Mihova D, Michalowski AM, Yuspa SH, Blumberg PM. Oncogene. 30(45): 4590-4600, 2011
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Molecular basis for failure of the "atypical" C1 domain of Vav1 to bind diacylglycerol / phorbol ester. Geczy T, Peach ML, El Kazzouli S, Sigano DM, Kang J, Valle CJ, Selezneva J, Woo W, Kedei N, Lewin NE, Garfield SH, Lim L, Mannan P, Marquez VE, Blumberg PM. J. Biol. Chem. 287: 13137-58, 2012
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Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action. Kedei N, Telek A, Michalowski AM, Kraft MB, Li W, Poudel YB, Rudra A, Petersen ME, Keck GE, Blumberg PM. Biochem. Pharmacol. 85: 313-24, 2013
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Molecular systems pharmacology: isoelectric focusing signature of protein kinase Cδ provides an integrated measure of its modulation in response to ligands. Kedei N, Chen J, Herrmann MA, Telek A, Goldsmith PK, Petersen ME, Keck GE, Blumberg PM. J. Med. Chem. 57: 5356-69, 2014
