R. Mark Simpson
Laboratory of Cancer Biology and Genetics
The Center for Cancer Research
United States of America
Biography
Dr. Simpson is a doctor of veterinary medicine graduate of the University of Georgia, Athens. He completed postgraduate clinical training in veterinary pathology and research training leading to a Ph.D. in comparative biomedical science at the Louisiana State University, Baton Rouge. He is specialty board certified by The American College of Veterinary Pathologists. Dr. Simpson was a faculty member and hematopathologist at the North Carolina State University Veterinary Medical Teaching Hospital, Raleigh. Subsequently he became a staff scientist with the National Institute of Allergy and Infectious Diseases intramural research program, Laboratory of Immunogenetics and the Infectious Diseases Pathogenesis Branch. In May 2001, Dr. Simpson joined the NCI Center for Cancer Research to establish and head the Molecular Pathology Unit, Laboratory of Cancer Biology and Genetics. He is founding director of the NIH Comparative Biomedical Scientist Training Program, an initiative to provide interdisciplinary training for veterinarians, in both diagnostic pathology and human disease-oriented medical research, to increase the synergy for comparative biomedical research interactions. This program is an NCI-administered component of the NIH Graduate Partnership Program and training leads to a Ph.D. and eligibility to certify as a veterinary pathologist. Dr. Simpson is adjunct graduate professor or clinical professor at 4 colleges of veterinary medicine, and serves as elected board member of the Executive Council, The American College of Veterinary Pathologists, and is immediate Past President (2016).
Research Interest
Cancer Biology, Computational Biology
Publications
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Mass spectrometry in cancer biomarker research: a case for immunodepletion of abundant blood-derived proteins from clinical tissue specimens. Prieto DA, Johann DJ, Wei BR, Ye X, Chan KC, Nissley DV, Simpson RM, Citrin DE, Mackall CL, Linehan WM, Blonder J. Biomark Med. 8: 269-86, 2014.
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Digital pathology and image analysis augment biospecimen annotation and biobank quality assurance harmonization. Wei BR, Simpson RM. Clin. Biochem. 47: 274-9, 2014.
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Bioluminescence imaging of ABCG2 efflux activity at the blood-placental barrier. JS Kumar, BR Wei, JP Madigan, RM Simpson, MD Hall, MM Gottesman Science Reports. 6: Nature 20418, 2016.