Smitha Antony
Developmental Therapeutics Branch
The Center for Cancer Research
United States of America
Biography
Dr. Smitha Antony is a staff scientist in the Oxidative Signaling and Molecular Therapeutics Group at the National Cancer Institute (NCI), NIH. She received her Ph.D. in microbiology and cell biology in 2001 from the Indian Institute of Science. Dr. Antony joined the NCI in 2002 and has made substantial contributions in the discovery and optimization of novel topoisomerase inhibitors, the indenoisoquinolines. Two indenoisoquinoline derivatives are in clinical trials at the NIH with histone γ-H2AX and Top1 levels used as pharmacodynamic biomarkers. Dr. Antony is the recipient of the Federal Technology Transfer Award and the NCI Certificate of Appreciation for recognition of outstanding contributions to research innovation for her work on human topoisomerase I (Top1) and human tyrosyl DNA phosphodiesterase I (Tdp1) inhibitors and the development and characterization of the NADPH oxidase 5 (NOX5) monoclonal antibody. Dr. Antony has co-authored many publications in the field of DNA damage and repair and holds several patents for inhibitors of DNA topoisomerases.
Research Interest
Cancer Biology, Clinical Research, Molecular Biology and Biochemistry, Molecular Pharmacology
Publications
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Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Antony S, Agama KK, Miao ZH, Takagi K, Wright MH, Robles AI, Varticovski L, Nagarajan M, Morrell A, Cushman M, Pommier Y. Cancer Res. 67: 10397-405, 2007.
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Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-? and lipopolysaccharide in human pancreatic cancer cell lines. Wu Y, Lu J, Antony S, Juhasz A, Liu H, Jiang G, Meitzler JL, Hollingshead M, Haines DC, Butcher D, Roy K, Doroshow JH. J. Immunol. 190: 1859-72, 2013.
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Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody. Antony S, Wu Y, Hewitt SM, Anver MR, Butcher D, Jiang G, Meitzler JL, Liu H, Juhasz A, Lu J, Roy KK, Doroshow JH. Free Radic. Biol. Med. 65: 497-508, 2013.
