Suresh V. Ambudkar
Head, Transport Biochemistry Section
The Center for Cancer Research
United States of America
Biography
Dr. Ambudkar obtained his Ph.D. from Madurai Kamaraj University, Madurai, India, and received his postdoctoral training in membrane bioenergetics at the University of Maryland. He continued his postdoctoral work on biochemistry of membrane transport proteins at the Johns Hopkins University School of Medicine. In July 1995, after 5 years as an assistant professor in the departments of medicine and physiology at Johns Hopkins, he joined the Laboratory of Cell Biology at the CCR, NCI. He serves as Deputy Chief of the Laboratory of Cell Biology and Chief of the Transport Biochemistry Section.
Research Interest
Cancer Biology, Cell Biology, Chemical Biology, Molecular Biology and Biochemistry, Molecular Pharmacology
Publications
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Shukla S, Chufan EE, Singh S, Skoumbourdis AP, Kapoor K, et al. (2014) Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna) with the human ABC drug transporter P-glycoprotein. Leukemia. 28: 961-4.
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Chufan EE, Kapoor K, Sim HM, Singh S, Talele TT, et al. (2013) Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1). PLoS ONE. 8: e82463.
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Sauna ZE, Ambudkar SV (2000) Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein. Proc Natl Acad Sci U S A. 97: 2515-20.
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Ambudkar SV, Cardarelli CO, Pashinsky I, Stein WD (1997) Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein. J. Biol. Chem. 272: 21160-6.
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Ambudkar SV, Lelong IH, Zhang J, Cardarelli CO, Gottesman MM, et al. (1992) Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. Proc. Natl. Acad. Sci. U.S.A. 89: 8472-6.
