Terrence R. Burke Jr.
Head, Bioorganic Chemistry Section
The Center for Cancer Research
United States of America
Biography
Dr. Burke received his B.S. in Chemistry from St. Martin's College, followed by his Ph.D. degree from the University of Washington under the direction of Professor Wendel Nelson. He then studied as a Fellow of the Pharmacology Associate Research Training Program in the Laboratory of Dr. Lance Pohl, National Heart Lung and Blood Institute and subsequently under the direction of Dr. Kenner Rice as a Senior Staff Fellow of the National Institute of Diabetes, Digestive and Kidney Diseases. He briefly left the NIH to serve as Principal Chemist of Peptide Technologies Corporation before returning in 1989 as a tenured Principal Investigator in the Chemical Biology Laboratory (previously, the Laboratory of Medicinal Chemistry). In 2002 he became Head of the Bioorganic and Medicinal Chemistry Section and in 2003 he was appointed a member of the Senior Biomedical Research Service (SBRS).
Research Interest
Cell Biology, Chemical Biology, Molecular Biology and Biochemistry, Molecular Pharmacology
Publications
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Zhao XZ; Smith SJ; Maskell DP; Metifiot M; Pye VE; et al. (2016) HIV-1 integrase strand transfer inhibitors with reduced susceptibility to drug resistant mutant integrases. ACS Chemical Biology. 11: 1074-1081.
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Qian WJ; Park JE; Grant R; Lai CC; Kelley JA; et al. (2015) A route to imidazolium-containing phosphopeptide macrocycles. Biopolymers Peptide Science. 104: 663-673.
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Liu F, Park JE, Qian WJ, Lim D, Scharow A, et al. (2012) Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1. ChemBioChem. 13: 1291-1296.
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Liu F, Park J, Qian W, Lim D, Scharow A, et al. (2012) Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification. ACS Chem Biol. 7: 805-10.
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Liu F, Park, JE, Qian WJ, Lim D, Yaffe MB, et al. (2011) Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel. Nat Chem Biol. 7: 595-601.
