Victor B. Zhurkin
Laboratory of Cell Biology
The Center for Cancer Research
United States of America
Biography
Dr. Zhurkin obtained his Ph.D. in molecular biophysics from the Moscow Physico-Technical Institute, and D.Sc. degree from the Lomonosov Moscow State University (Russia), and continued his research on DNA conformational mechanics in the Engelhardt Institute of Molecular Biology (Moscow, Russia). Since 1989, he has been at the National Cancer Institute, where he has studied structural aspects of the protein-DNA interactions in large nucleoprotein assemblages such as nucleosomes, the Gal-repressosome, recombination filaments, transcription elongation complexes, and a tetrameric p53-DNA complex.
Research Interest
Chromosome Biology, Computational Biology, Genetics and Genomics, Molecular Biology and Biochemistry, Structural Biology
Publications
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Karamychev VN, Wang D, Mazur SJ, Appella E, Neumann RD, et al. (2012) Radioprobing the conformation of DNA in a p53-DNA complex. Int. J. Radiat. Biol. 88: 1039-45.
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Macvanin M, Edgar R, Cui F, Trostel A, Zhurkin V, et al. (2012) Noncoding RNAs binding to the nucleoid protein HU in Escherichia coli. J. Bacteriol. 194: 6046-55.
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Nikitina T, Wang D, Gomberg M, Grigoryev SA, Zhurkin VB (2013) Combined micrococcal nuclease and exonuclease III digestion reveals precise positions of the nucleosome core/linker junctions: implications for high-resolution nucleosome mapping. J. Mol. Biol. 425: 1946-60.
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Zhurkin VB, Olson WK (2013) Can nucleosomal DNA be described by an elastic model?: comment on "Sequence-dependent collective properties of DNAs and their role in biological systems" by Pasquale De Santis and Anita Scipioni. Phys Life Rev. 10: 70-2.
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Cui F, Zhurkin VB (2014) Rotational positioning of nucleosomes facilitates selective binding of p53 to response elements associated with cell cycle arrest. Nucleic Acids Res. 42: 836-47.
