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Molecular Biology Experts

Vineet N. Kewalramani


Basic Research Laboratory
The Center for Cancer Research
United States of America

Biography

Dr. Vineet N. KewalRamani first developed an interest in retroviruses as an undergraduate in the University of Wisconsin at Madison. After choosing to pursue molecular biology as a career, he enrolled in the graduate program at the University of Washington in Seattle where he studied HIV molecular replication at the Fred Hutchinson Cancer Research Center. Upon completing his Ph.D. training in 1996, he received a fellowship from the Damon Runyon Cancer Research Foundation and a postdoctoral position from New York University where he examined HIV infection within an immunological context. While working in NYU, he joined in an effort to develop a mouse model for HIV replication using transgenic technologies. These studies provided the foundation for his group's current work at the National Cancer Institute. Today, his team investigates the role of host factors in HIV infection and the biology of HIV in animal models. HIV and other retroviruses hack the host organism's genetic program to propagate their code. They also rapidly evolve in the face of selective pressure. By illuminating how retroviruses co-opt host functions while evading antiviral drugs or immune responses, his lab seeks to develop new strategies to impede the dynamic viral program. Dr. KewalRamani was the 2011 and 2012 chair of the National Institutes of Health (NIH) Earl Stadtman Virology Search Committee and a co-organizer of the Cold Spring Harbor Laboratory 37th annual meeting on Retroviruses held in May of 2012. He is a past chair of the NIH Norman Salzman Virology Scientific Committee. He has served on the editorial boards of Journal of Virology, PLoS ONE, Retrovirology, and Virology. He was tenured by the NIH in 2010. 

Research Interest

Cell Biology, Immunology, Molecular Biology and Biochemistry, Virology 

Publications

  • Lee K, Ambrose Z, Martin T, Oztop I, Mulky A, et al. (2010) Flexible use of nuclear import pathways by HIV-1. Cell Host Microbe. 7: 221-233.

  • Lee K, Mulky A, Yuen W, Martin TD, Meyerson NR, et al. (2012) HIV-1 capsid-targeting domain of cleavage and polyadenylation specificity factor 6. J Virol. 3851-60.

  • Ambrose Z, Lee K, Ndjomou J, Xu H, Oztop I, et al. (2012) Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection. J. Virol. 86: 4708-14.

  • Price AJ, Fletcher AJ, Schaller T, Elliott T, Lee K, et al. (2012) CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication. PLoS Pathog. 8: e1002896.

  • Hatziioannou T, Del Prete GQ, Keele BF, Estes JD, McNatt MW, et al. (2014) HIV-1-induced AIDS in monkeys. Science 344: 1401-1405.

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