Xiao-jiang Gao
Cancer and Inflammation Program
The Center for Cancer Research
United States of America
Biography
Dr. Gao graduated from Beijing Second Medical College, China. After a brief residency he started his research career at the Beijing Lung Tumor Institute. From 1986-1990 he was a visiting research fellow in the South Western Medical Center in Dallas, Texas. He went on to become a Ph.D. scholar at the John Curtin School of Medical Research, Australian National University in Canberra, Australia and received his Ph.D. in human genetics in 1993. Dr. Gao is currently a senior scientist with Leidos Biomedical, Inc., and works in the Cancer and Inflammation Inflammation Program. His research interests are mainly focused on the genetic diversity of human populations and its impact on diseases, in particular, the polymorphism of MHC genes and its interaction with killer immunoglobulin-like receptors (KIR) genes.
Research Interest
1. Characterization of the genetic diversity of HLA genes. High-resolution and large-throughput molecular gene typing for class I and class II HLA genes for disease cohorts have become a prerequisite for understanding the role played by these highly polymorphic immunogenetic genes. Inherited genetic variations at the nucleotide as well as peptide level provide crucial information to the understanding of disease pathogenesis. 2. Interaction between MHC and KIR and its impact on cancer and infectious disease. Investigation of both MHC and KIR genes provides insights into the synergistic interaction between the two highly polymorphic immunogenetic systems and its relevance to cancer and infectious diseases and lead to an overall understanding of the cross-passing between the acquired immunity and innate immunity.
Publications
-
Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease. Kulkarni S, Qi Y, O'hUigin C, Pereyra F, Ramsuran V, McLaren P, Fellay J, Nelson G, Chen H, Liao W, Bass S, Apps R, Gao X, Yuki Y, Lied A, Ganesan A, Hunt PW, Deeks SG, Wolinsky S, Walker BD, Carrington M. Proc Natl Acad Sci U S A. 110: 20705-10, 2013.
-
Association of HLA-DRB1-restricted CD4? T cell responses with HIV immune control. Ranasinghe S, Cutler S, Davis I, Lu R, Soghoian DZ, Qi Y, Sidney J, Kranias G, Flanders MD, Lindqvist M, Kuhl B, Alter G, Deeks SG, Walker BD, Gao X, Sette A, Carrington M, Streeck H. Nat Med. 19: 930-3, 2013.
-
Associations between human leukocyte antigen class I variants and the Mycobacterium tuberculosis subtypes causing disease. Salie M, van der Merwe L, Möller M, Daya M, van der Spuy GD, van Helden PD, Martin MP, Gao XJ, Warren RM, Carrington M, Hoal EG. J Infect Dis. 209: 216-23, 2014.
