Zheng-gang Liu
Laboratory of Immune Cell Biology
The Center for Cancer Research
United States of America
Biography
Dr. Liu received both his bachelor's and master's degrees in biochemistry from Peking University, People's Republic of China. He completed his Ph.D. training in Dr. Larry Schwartz's laboratory at the University of Massachusetts and carried out his postdoctoral training in the laboratory of Dr. Michael Karin at the University of California, San Diego. He joined the former Department of Cancer and Cell Biology, Medicine Branch, DCS, in 1998 and became a senior investigator in 2005. His research interests have focused on the molecular mechanisms of apoptosis and necrosis and the role of cell death and inflammation in tumorigenesis.
Research Interest
Cancer Biology, Cell Biology, Clinical Research, Immunology, Molecular Biology and Biochemistry
Publications
-
Kim YS, Morgan MJ, Choksi S, Liu ZG (2007) TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol. Cell. 26: 675-87.
-
Pobezinskaya YL, Kim YS, Choksi S, Morgan MJ, Li T, et al. (2008) The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. Nat. Immunol. 9: 1047-54.
-
Li T, Morgan MJ, Choksi S, Zhang Y, Kim YS, et al. (2010) MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation. Nat. Immunol. 11: 799-805.
-
Choksi S, Lin Y, Pobezinskaya Y, Chen L, Park C, et al. (2011) A HIF-1 target, ATIA, protects cells from apoptosis by modulating the mitochondrial thioredoxin, TRX2. Mol. Cell. 42: 597-609.
-
Cai Z, Jitkaew S, Zhao J, Chiang H, Choksi S, et al. (2014) Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nat. Cell Biol. 16: 55-65.
