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Biochemistry Experts

Zhi-ming Zheng


RNA Biology Laboratory
The Center for Cancer Research
United States of America

Biography

Dr. Zhi-Ming Zheng received his medical and virological training in China (1981) and was a Yale-China Exchange Scholar in clinical virology at Yale University (1981-1984). Dr. Zheng served as Associate Professor, Chief of the Clinical Virology Laboratory, and Deputy/Acting Director of the Virus Research Institute, Wuhan University School of Medicine, China (1985-1990). He was Vice-President of the Chinese Society of Medical Virology (1988-1990). He first isolated enterovirus type 71 (EV71, ATCC VR-1432) in China from the vesicle fluid of a hand, foot, and mouth disease patient and identified a new poxvirus named epidemic erythromelagia-related poxvirus (ERPV, ATCC VR-1431). He and John Huggins at the US Army Medical Research Institute of Infectious Diseases led the first clinical trial of intravenous ribavirin therapy for hemorrhagic fever with renal syndrome (HFRS) caused by hantavirus infection in China (1985-1989). He received his Ph.D. from the University of South Florida School of Medicine (1994). He was an IRTA fellow and later a senior staff in the Laboratory of Tumor Virus Biology before heading his section in the HIV and AIDS Malignancy Branch in 2000, the Gene Regulation and Chromosome Biology Laboratory in 2013 and the RNA Biology Laboratory of NCI in 2016. His research interests center on the RNA processing and tumorigenesis of tumor viruses including papillomaviruses and Kaposi's sarcoma-associated herpesvirus. He organized the 24th International Papillomavirus Conference and Clinical Workshop, Beijing, China, Nov. 3-9, 2007 and was a recipient of the 2009 NCI Director Award, 2010 NIH Award of Merit, 2016 NCI Outstanding Mentor Award and 2016 NIH APAO Outstanding Scientific Achievement Award. He was elected as a member of the American Academy of Microbiology in 2014. 

Research Interest

Cancer Biology, Cell Biology, Clinical Research, Molecular Biology and Biochemistry, Virology 

Publications

  • Majerciak M, Zheng ZM (2016) Alternative RNA splicing of KSHV ORF57 produces two different RNA isoforms. Virology. 488: 81-87.

  • Sharma NR, Wang X, Majerciak V, Ajiro M, Kruhlak M, et al. (2016) Cell Type- and Tissue Context-dependent Nuclear Distribution of Human Ago2. J. Biol. Chem. 291: 2302-2309.

  • Ajiro M, Jia R, Yang Y, Zhu J, Zheng ZM (2016) A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells. Nucleic Acid Res. 44: 1854-1870.

  • Ajiro M, Tang S, Doorbar J, Zheng ZM (2016) SRSF3 and hnRNP A1 regulate alternative RNA splicing and gene expression of human papillomavirus type 18 through two functionally distinguishable cis-elements. Journal of Virology. 90: 9138-9152.

  • Xiaohong Wang, Haibin Liu, Hui Ge, Masahiko Ajiro, et al. (2017) Viral DNA Replication Orientation and hnRNPs Regulate Transcription of the Human Papillomavirus 18 Late Promoter. mBio. 8: e00713-17.

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