Ann Bode
Professor
Cancer Biomarkers & Drug Resistance
The Hormel Institute
United States of America
Biography
Ann M. Bode is the Associate Director of The Hormel Institute and leader of Biomarkers and Drug Resistance and co-leader of Molecular and Cellular Biology research sections at The Hormel Institute. Dr. Bode received her B.S. and M.S. from Southern Illinois University and her Ph.D. from the University of Oregon. She did her post-doctoral work in the Department of Biochemistry in the School of Medicine at the University of North Dakota. She was a full-time tenured faculty member in the Department of Physiology in the School of Medicine where she was Director of Graduate Studies, Head of Cardiovascular Physiology for First Year Medical Students, and ran a research program specializing in the role of reactive oxygen species and antioxidants in chronic diseases, including cancer and diabetes. Prior to receiving her Ph.D., Dr. Bode spent many years as a college women’s athletic director and volleyball coach.
Research Interest
Molecular mechanisms of carcinogenesis and chemoprevention of cancer, -Signal transduction pathways (MAP kinases, S6 kinases) and transcription factors (AP-1, NF-kB, NFAT, p53) in development, and disease, -Molecular mechanisms of chemopreventive effect of natural dietary compounds especially [6]-gingerol, tea polyphenols and resveratrol, -Targeting transcription factors for cancer prevention and treatment, , -Oxidative stress, ultraviolet, arsenic and other environmental human carcinogen-induced signal transduction pathways and carcinogenesis, -Cancer biomarkers and drug resistance.
Publications
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Yao, K., et al. (2014) JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity. Stem Cell Res, 12, 139-52.
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Yu, X., et al. (2014) Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFalpha and ROS production. Oncotarget.
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Bode, A.M., et al. (2015) Toxic Phytochemicals and Their Potential Risks for Human Cancer. Cancer Prev Res (Phila), 8, 1-8.