William E. Balch
Professor
Molecular Medicine
The Scripps Research Institute
United States of America
Biography
Professor, Molecular Medicine , The Scripps Research Institute 2017
Research Interest
Molecular basis for membrane trafficking and protein folding disease Our laboratory is interested in understanding the rules that direct protein traffic through secretory pathway of eukaryotic cells. We use structural, biochemical, morphological and molecular tools to study mechanisms of protein folding and protein-protein interactions that mediate membrane vesicle targeting and fusion. We are particularly interested in defining the key trafficking defects that lead to hereditary amyloid disease, childhood emphysema, and cystic fibrosis, all diseases related to the inability of specific proteins to be properly transported to their site of function in the cell.
Publications
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Amaral MD, Balch WE (2015) Hallmarks of therapeutic management of the cystic fibrosis functional landscape. J Cyst Fibros. pii: S1569-1993.
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Calzolari, D, Martinez-Bartolome S, Lavallee-Adam M, Balch WE, Yates JR, et al. (2015). F508 CFTR interactome remodelling promotes rescue of cystic fibrosis. Nature 528:510-6.
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Wang C, Balch WE (2016). Managing the adaptive proteostatic landscape: restoring resilience in Alpha-1 antitrypsin deficiency. In: Adam Wanner, M.a.R.A.S., MD, Ph.D editor. Respir. Med.: Humana Press - Springer International Publishing AG Switzerland pp: 53-83.
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Pipalia NH, Subramanian K, Mao S, Ralph H, Hutt DM, et al. (2017) Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells. J. Lipid Res. 58:695-708.
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Wang C, Bouchecareilh M, Balch WE (2017) Measuring the Effect of Histone Deacetylase Inhibitors (HDACi) on the Secretion and Activity of Alpha-1 Antitrypsin. Methods Mol. Biol 1639:185-193.
