Richard Fehon
Chairman, Molecular Genetics and Cell Biology
Molecular Genetics and Cell Biology
The University of Chicago
United States of America
Biography
Education: (1986-1991) Postdoctoral Fellow with Spyros Artavanis-Tsakonas, Depts. of Biology and Cell Biology, Yale University and HHMI. (1980-1986) Ph.D., Department of Zoology and Developmental Biology Training Program, University of Washington, Seattle, Dissertation Research with Gerold Schubiger. (1978-1980) BS (magna cum laude) Department of Zoology, Duke University, Durham, NC. Professional Experience: (2007 - present) Chair of Molecular Genetics and Cell Biology, University of Chicago. (2005 - present) Professor of Molecular Genetics and Cell Biology, University of Chicago. (2002-2004) Co-Director, Duke University Model Systems Genomics Unit. (2002-2004) Convener, Developmental, Cell, and Molecular Biology Group, Department of Biology, Duke University, Durham, NC (2001-2004) Director of Graduate Studies, Developmental Biology Training Program, Duke University, Durham, NC. (2000-2004) Associate Professor of Biology, Duke University, Durham, NC. (1999-2000) Associate Professor of Zoology, Duke University, Durham, NC. (1992-1998) Assistant Professor of Zoology, Duke University, Durham, NC. (1989-1991) NIH Postdoctoral Fellow, Yale University, New Haven, CT. (1986-1989) ACS Postdoctoral Fellow, Yale University, New Haven, CT. (1982-1986) NIH Predoctoral Fellow, University of Washington, Seattle, WA.
Research Interest
Research interests center on the molecular mechanisms by which signal transduction pathways are organized into specialized membrane domains. In addition to their known role in organizing receptors and downstream effectors into functional signaling complexes, such organized complexes function to integrate signaling activities from multiple pathways and to segregate simultaneous but distinct functions of a single pathway. We study this question in Drosophila because of the utility of this system for studying the functions of individual genes via mutagenesis, and for examining the functional interactions between different genes that work together in a particular cellular or developmental process.
Publications
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Nilton, A., Oshima, K., Zare, F., Byri, S., Nannmark, U., Nyberg, K.G., Fehon, R.G., and Uv, A.E. Crooked, Coiled and Crimpled are three Ly6-like proteins required for proper localization of septate junction components. Development. 2010 137: 2427-37. (PubMed)
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Neisch, A.L., Speck, O., Stronach, B., and Fehon, R.G. Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane. J. Cell Biol. 2010 189: 311-23. (PubMed)
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Oshima, K. and Fehon, R.G. Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs Large. J. Cell Sci. 2011 124: 2861-71. (PubMed)
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Boggiano, J.C, Vanderzalm, P.J. and Fehon, R.G. Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. Dev. Cell. 2011 21:888-895. (PubMed)
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Boggiano, J.C and Fehon, R.G. Growth control by committee: Intercellular junctions, cell polarity, and the cytoskeleton regulate Hippo signaling. Dev. Cell. 2012 22: 695-702. (PubMed)