Andrew Doig
Professor
The University of Manchester
United States of America
Biography
He is a professor in chemistry department.
Research Interest
Alzheimer’s Disease is caused by the aggregation of the beta-amyloid peptide into toxic oligomers. We design and discover new drugs to interfere with beta-amyloid production and deposition, and reduce its toxicity. For example, we have rationally designed modified peptides to act as inhibitors of beta-amyloid aggregation and toxicity. Drugs are tested with a variety of biophysical and toxicity assays in Manchester, and in vivo by collaborators, to characterise in detail how they work. We are currently screening compound libraries to find new drugs.
