Daniel L. Baker
Associate Professor
Department of Chemistry
The University of Memphis
United States of America
Biography
Dr. Baker joined the Department of Chemistry at the University of Memphis in 2006, following three years as an Assistant Professor at the University of Tennessee Health Science Center. Research in the Baker lab focuses on the analysis and characterization of bioactive lipids (lysophosphatidic acid, sphingosine 1-phosphate, and phosphatidic acid) and their roles in human biochemistry and disease. The overall goal of the lab is to better understand the mechanisms by which these specific bioactive lipids are produced and how they elicit their responses. A deeper understanding of these processes may open doors for the design of future therapeutics. Dr. Baker's expertise lies in the application of analytical biochemistry to the study of enzyme function. Research projects are conducted through interdisciplinary interactions with collaborators within the University of Memphis and beyond. Dr. Baker's major teaching focus has been CHEM3511, Foundations of Bioorganic Chemistry since 2010. However, he has also taught special topic courses on Chemical Biology and Protein Mass Spectrometry.
Research Interest
Bio molecules, Enzyme and Biochemistry
Publications
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Fells, J.I., Lee, S.C., Fujiwara, Y., Norman, D.D., Lim, K.G., Tsukahara, R., Liu,J., Patil, R., Miller, D.D., Kirby, R.J., Nelson, S., Seibel, W., Papoian, R., Parrill, A.L., Baker, D.L., Bittman, R., and Tigyi, G., (2013) Hits of a High-Throughput Screen Identify the Hydrophobic Pocket of Autotaxin/ Lysophospholipase D as an Inhibitory Surface, Mol. Pharmacol., 84(3):415-424.
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Norman, D.D., Ibezim, A., Scott, W.E., White, S., Parrill, A.L., and Baker, D.L.,(2013) Autotaxin Inhibition: Development and Application of Computational Tools to Identify Site-Selective Lead Compounds, Bioorg. & Med. Chem., 21(17);5548-5560.
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Fells, J.I., Lee, S.C., Norman, D.D., Tsukahara, R., Kirby, J.R., Nelsen, S., Seibel, W., Papoian, R., Patil, R., Miller, D.D., Parrill, A.L., Pham, T., Baker,D.L., Bittman, R. and Tigyi, G., (2014) Targeting the Hydrophobic Pocket of Autotaxin with Virtual Screening of Inhibitors Identifies a Common Aromatic Sulfonamide Structural Motif, FEBS J., 281(4):1017-1028.
