Microbiology Experts

Ambro Van Hoof

Department of Microbiology and Molecular Genetics
The University of Texas Health Science Center
United States of America


I was born and raised in the Netherlands. I first learned about molecular genetics during my undergraduate education at Wageningen Agricultural University. I decided to pursue molecular genetics for my graduate education at the DOE Plant Research Lab at Michigan State University. During my graduate work I studied mRNA quality control and degradation pathways in plants. After receiving my PhD, I continued studying mRNA degradation pathways, but switched to using yeast because of the better experimental tools available, and because yeast is more closely related to humans. These post-doctoral studies led me to the RNA exosome, and I have been fascinated by its functions ever since.

Research Interest

mRNA degradation and quality control of gene expression


  • Losh JS, van Hoof A. Gateway Arch to the RNA Exosome. Cell. 2015 Aug 27;162(5):940-1.

  • Han J, van Hoof A. The RNA Exosome Channeling and Direct Access Conformations Have Distinct In Vivo Functions. Cell Rep. 2016 Sep 20;16(12):3348-3358.

  • Fasken MB, Losh JS, Leung SW, Brutus S, Avin B, Vaught JC, Potter-Birriel J, Craig T, Conn GL, Mills-Lujan K, Corbett AH, van Hoof A. Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast. Genetics. 2017 Jan;205(1):221-237.

  • Gao P, Pinkston KL, Bourgogne A, Murray BE, van Hoof A, Harvey BR. Functional studies of E. faecalis RNase J2 and its role in virulence and fitness. PLoS One. 2017 Apr 6;12(4):e0175212.

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