Microbiology
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Anne-marie Krachler

Associate Professor
Department of Microbiology and Molecular Genetics
The University of Texas Health Science Center
United States of America

Anne-marie Krachler

Biography

Dr. Krachler joined the faculty of the McGovern Medical School, Department of Microbiology and Molecular Genetics at the University of Texas Health Science Center at Houston as an Associate Professor in September 2016. She completed her undergraduate and masters degree in Chemical Engineering at the Vienna University of Technology, Austria, before training for a Ph.D. in Biochemistry with Colin Kleanthous at the University of York in the UK. After joining Kim Orth’s lab at UT Southwestern Medical Center as a postdoctoral fellow, she moved to the University of Birmingham as an EMBO Fellow and Birmingham Fellow in 2012, where she first established her independent laboratory. Dr Krachler’s research on bacteria-host interactions has been recognized by several awards, including a Texas Rising STAR award (2016), the Biochemical Society’s Early Career Research Award for Biological Systems (2015) and a Founder’s Award (2015).

Research Interest

Developing adhesion inhibitors to counteract bacterial infections,Manipulating bacterial behaviour by building synthetic microbial communities, Discovering how bacteria perceive and react to mechanical cues in the GI tract to initiate colonization

Publications

  • Stones DH, Krachler AM. Dual function of a bacterial protein as an adhesin and extracellular effector of host GTPase signaling. Small GTPases. 2015;6(3):153-6.

  • Lim J, Stones DH, Hawley CA, Watson CA, Krachler AM. Multivalent adhesion molecule 7 clusters act as signaling platform for host cellular GTPase activation and facilitate epithelial barrier dysfunction. PLoS Pathog. 2014 Sep 25;10(9):e1004421.

  • Stones DH, Krachler AM. Fatal attraction: how bacterial adhesins affect host signaling and what we can learn from them. Int J Mol Sci. 2015 Jan 23;16(2):2626-40.

  • Mahmoud RY, Stones DH, Li W, Emara M, El-Domany RA, Wang D, Wang Y, Krachler AM, Yu J. The Multivalent Adhesion Molecule SSO1327 plays a key role in Shigella sonnei pathogenesis. Mol Microbiol. 2016 Feb;99(4):658-73.

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