Department of Microbiology and Molecular Genetics
The University of Texas Health Science Center
United States of America
I received my Ph.D. in Microbiology from the Institute of Microbiology, Chinese Academy of Sciences, Beijing, China in 2007. After graduation I joined Dr. Fengxia Qi’s lab at the Department of Oral Biology, College of Dentistry, University of Oklahoma Health Sciences Center as a Research Fellow where I studied oral bacterium Streptococcus mutans. Then, in 2009, I moved to the Department of Microbiology & Molecular Genetics, University of Texas Health Sciences Center in Houston, Texas as a postdoctoral fellow working with Dr. Hung Ton-That to elucidate the mechanism of surface pilus assembly on Gram-positive bacteria. My current research primarily focuses on revealing the molecular mechanisms underlying interspecies interactions between Fusobacterium nucleatum with other oral bacteria.
Molecular mechanisms of polymicrobial interactions in Fusobacterium nucleatum
Reardon-Robinson ME, Osipiuk J, Chang C, Wu C, Jooya N, Joachimiak A, Das A, Ton-That H. A Disulfide Bond-forming Machine Is Linked to the Sortase-mediated Pilus Assembly Pathway in the Gram-positive Bacterium Actinomyces oris. The Journal of biological chemistry. 2015; 290(35):21393-405.
Wu C, Reardon-Robinson ME, Ton-That H. Genetics and Cell Morphology Analyses of the Actinomyces oris srtA Mutant. Methods in molecular biology (Clifton, N.J.). 2016; 1440:109-22.
Siegel SD, Wu C, Ton-That H. A Type I Signal Peptidase Is Required for Pilus Assembly in the Gram-Positive, Biofilm-Forming Bacterium Actinomyces oris. Journal of bacteriology. 2016; 198(15):2064-73.
Juárez-Vázquez AL, Edirisinghe JN, Verduzco-Castro EA, Michalska K, Wu C, Noda-García L, Babnigg G, Endres M, Medina-Ruíz S, Santoyo-Flores J, Carrillo-Tripp M, Ton-That H, Joachimiak A, Henry CS, Barona-Gómez F. Evolution of substrate specificity in a retained enzyme driven by gene loss. eLife. 2017; 6.