Microbiology
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William Margolin

Professor
Department of Microbiology and Molecular Genetics
The University of Texas Health Science Center
United States of America

William Margolin

Biography

Dr. Margolin grew up in Tenafly, NJ, near New York City. He attended M.I.T. as an undergraduate, where he worked on E. coli genetics research with Graham Walker, and biochemical engineering research on thermophilic clostridia with Daniel I.C. Wang. He then did his Ph.D. work on transcriptional regulation in bacteriophage Mu with Martha Howe at University of Wisconsin-Madison. He followed this with an NSF postdoctoral fellowship in Plant Biology with Sharon Long at Stanford, where he studied the role of FtsZ in cell division of rhizobia. He joined the MMG department in 1993 to begin his long-standing investigation of bacterial cell division and organization.

Research Interest

Targeting and assembly of the bacterial cell division complex

Publications

  • Rowlett VW, Mallampalli VKPS, Karlstaedt A, Dowhan W, Taegtmeyer H, Margolin W, Vitrac H. Impact of Membrane Phospholipid Alterations in Escherichia coli on Cellular Function and Bacterial Stress Adaptation. J Bacteriol. 2017 Jun 13;199(13). pii: e00849-16.

  • Schoenemann KM, Margolin W. Bacterial Division: FtsZ Treadmills to Build a Beautiful Wall. Curr Biol. 2017 Apr 24;27(8):R301-R303.

  • Krupka M, Rowlett VW, Morado D, Vitrac H, Schoenemann K, Liu J, Margolin W. Escherichia coli FtsA forms lipid-bound minirings that antagonize lateral interactions between FtsZ protofilaments. Nat Commun. 2017 Jul 11;8:15957.

  • Fan Y, Evans CR, Barber KW, Banerjee K, Weiss KJ, Margolin W, Igoshin OA, Rinehart J, Ling J. Heterogeneity of Stop Codon Readthrough in Single Bacterial Cells and Implications for Population Fitness. Mol Cell. 2017 Sep 7;67(5):826-836.e5.

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