Department of Microbiology and Molecular Genetics
The University of Texas Health Science Center
United States of America
After receiving my Ph.D. degree from Institute of Genetics of the Chinese Academy of Sciences in Beijing, I was fascinated by the ubiquitin-proteasome system and joined Dr. C.C. Wang’s laboratory at University of California-San Francisco as a postdoc fellow. I established a relationship between the ubiquitin-proteasome system and cell cycle regulation in Trypanosoma brucei, and initiated a project aiming to dissect the unusual mechanisms of cell cycle control in this parasitic protozoan. During 2003 to 2005, I worked as a research fellow at Temasek Life Sciences Laboratories in Singapore, and from 2005 to 2009 I was an assistant research scientist (assistant research professor) at UCSF. In 2009 I moved to the University of Texas-Houston Medical School to start my own laboratory. I am currently a faculty member of UTHealth Medical School at Houston and UT Graduate school of Biomedical Sciences. I am also an adjunct faculty member at the National School of Tropical Medicine of Baylor College of Medicine.
Cell cycle regulation in trypanosomes
Liao S, Hu H, Wang T, Tu X, Li Z. The Protein Neddylation Pathway in Trypanosoma brucei: FUNCTIONAL CHARACTERIZATION AND SUBSTRATE IDENTIFICATION. J Biol Chem. 2017 Jan 20;292(3):1081-1091.
Dang HQ, Zhou Q, Rowlett VW, Hu H, Lee KJ, Margolin W, Li Z. Proximity Interactions among Basal Body Components in Trypanosoma brucei Identify Novel Regulators of Basal Body Biogenesis and Inheritance. MBio. 2017 Jan 3;8(1). pii: e02120-16.
Hu H, Zhou Q, Han X, Li Z. CRL4WDR1 Controls Polo-like Kinase Protein Abundance to Promote Bilobe Duplication, Basal Body Segregation and Flagellum Attachment in Trypanosoma brucei. PLoS Pathog. 2017 Jan 4;13(1):e1006146.
Liu Z, Han X, Zhou Q, Chen R, Fruge S, Jo MC, Ma Y, Li Z, Yokoi K, Qin L. Integrated Microfluidic System for Gene Silencing and Cell Migration. Adv Biosyst. 2017 Jun;1(6). pii: 1700054.