John T. Pinto
Professor
Biochemistry and Molecular Biology
Touro College
United States of America
Biography
Dr. Pinto’s laboratory focuses on mechanisms by which diet-derived factors prevent primary and secondary prostrate and colon cancer development. Our studies show that sulfur- and selenium-containing amino acids can be converted to direct-acting metabolites whose intracellular levels depend on tissue expression of specific transaminase enzymes.
Research Interest
Identifying chemopreventive strategies for diminishing primary and secondary cancer risks, Investigations examine effects of organosulfur, organoselenium and polyphenolic compounds on redox responsive metabolic pathways within human prostate, breast, and colon cancer cells.
Publications
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Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter. Carcinogenesis 29(9): 1816-1824, 2008.
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Effects of naturally occurring and synthetic organoselenium compounds on protein profiling in androgen responsive and androgen independent human prostate cancer cells. Nutr Cancer 60(2): 267-275, 2008.
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Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cells. Int J Cancer 120(7): 1410-1417, 2007.
