Haiyong Han
Professor
Clinical Translational Research Division
Translational Genomics Research Institute
United States of America
Biography
Dr. Haiyong Han is the Professor of Clinical Translational Research Division in Translational Genomics Research Institute and Head of Basic Research Unit, Pancreatic Cancer Program. Dr. Han's lab is investigating the molecular mechanism of perineural invasion in pancreatic cancer. Perineural invasion is one of the most common features of pancreatic cancer and it causes pain. This pain has a tremendous impact on the patient quality of life. By understanding the mechanism of perineural invasion, we hope to identify molecular targets for the development of therapeutics that may alleviate the pain suffered by pancreatic cancer patients.
Research Interest
identification of frequent alterations responsible for driving the onset and progression of pancreatic cancer and the development of new anti-pancreatic cancer agents that target these alterations. genomic and biochemical approaches including whole genome expression profiling (DNA microarrays), gene copy number analysis (CGH microarrays), and tissue array immunohistochemistry to identify alterations in pancreatic cancer cells. tumor suppressor genes. molecular mechanism of perineural invasion in pancreatic cancer.
Publications
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Small interfering RNA-mediated knockdown of PRL phosphatases results in altered Akt phosphorylation and reduced clonogenicity of pancreatic cancer cells Mol Cancer Ther Jan;7(1):202-10 2008
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UA62784, a novel inhibitor of centromere protein E kinesin-like protein Mol Cancer Ther Jan;8(1):36-44 2009
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Identification of pancreatic cancer-specific cell-surface markers for development of targeting ligands. Methods Mol Biol 624:195-210 2010
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Cell cycle arrest and apoptosis induction by an anticancer chalcone epoxide. Arch Pharm 343:429-439. 2010
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Targeting loss-of-function mutations in tumor-suppressor genes as a strategy for development of cancer therapeutic agents Semin Oncol Aug;33(4):513-20 2006
