Isabelle Schrauwen
Research Assistant Professor
Neurogenomics Division
Translational Genomics Research Institute
United States of America
Biography
Dr. Schrauwen received her M.S. in Biomedical Sciences from the University of Antwerp (Belgium) in 2005, with molecular biology and genetics as specialization. In 2010, she received her Ph.D. in Biomedical Sciences at the University of Antwerp. Her dissertation research focused on identifying genetic factors involved in otosclerosis, a progressive form of hereditary hearing loss. She remained a postdoc at the University of Antwerp, and in November 2011, Dr. Schrauwen was awarded with a travel award to visit the Translational Genomics Research Institute to continue her work in collaboration with Dr. Huentelman. Dr. Schrauwen joined TGen as a research assistant professor in 2015.
Research Interest
Identification of key pathways and pathogenic mechanisms important in sensory disorders, gene identification and characterization for several forms of hearing loss, autoimmune neuro-inflammatory disorders that involve sensory symptoms, like necrotizing meningoencephalitis in the dog and multiple sclerosis.
Publications
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Autosomal recessive Stickler syndrome in two families caused by mutations in the COL9A1 gene. Invest Ophthalmol Vis Sci. 2011 Jul 1;52(7):4774-9.
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A genome wide analysis identifies genetic variants in the RELN gene associated with otosclerosis. Am J Hum Genet. 2009 Mar;84(3):328-38.
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The coding polymorphism T263I in TGF-beta1 is associated with otosclerosis in two independent populations. Hum Mol Genet. 2007 Sep 1;16(17):2021-30.
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A sensitive and specific diagnostic test for hearing loss using a microdroplet PCR-based approach and next generation sequencing. Am J Med Genet A. 2013 Jan;161(1):145-52.
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Identification of novel genetic risk loci in Maltese dogs with necrotizing meningoencephalitis and evidence of a shared genetic risk across toy dog breeds. 2014. PLoS One. 2014Nov 13;9(11):e112755.
