William Hendricks
Assistant Professor
Integrated Cancer Genomics Division
Translational Genomics Research Institute
United States of America
Biography
Dr. Hendricks received joint baccalaureates in Literature from Grand Canyon University and Molecular Biosciences and Biotechnology from Arizona State University. He completed his doctoral work in the Cellular and Molecular Medicine Program at Johns Hopkins School of Medicine where he trained in cancer genomics and experimental therapeutics in the laboratory of Drs. Kenneth Kinzler and Bert Vogelstein with his thesis work centered on nanoparticle-based cancer gene therapy. His postdoctoral work then focused on viral cancer therapeutics within this group. He joined TGen in 2013 to work with Drs. Jeffrey Trent and Aleksandar Sekulic to develop programs in genomics-guided medicine and therapeutic innovation in human melanoma and beyond.
Research Interest
Cellular and Molecular Medicine, viral cancer therapeutics, Integrating genomic and therapeutic analyses of pediatric cancers, Mapping canine cancer landscapes for identification of actionable targets to guide comparative clinical trials, Dissecting biological determinants of therapeutic vulnerability in human melanoma through integrated analysis of large-scale data sets.
Publications
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Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4. Nature Genetics. 2014 May; 46:427-429.
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Prospective Molecular Profiling of Canine Cancers Provides a Clinically Relevant Comparative Model for Evaluating Personalized Medicine (PMed) Trials. PLoS One. 2014 March; 9(3):1-12.
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Nanoparticle Formulation that Selectively Transfects Metastatic Tumors in Mice. Proceedings of the Naional Academy of Sciences. 2013; 110(36), 14717-14722.
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Genetics and Individualized Treatment for Colorectal Cancer. Practical Gastroenterology. 2012 June; 36(6):28-35.
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Formulating the Magic Bullet: Barriers to Clinical Translation of Nanoparticle Cancer Gene Therapy. Nanomedicine. 2014 August. 9(8):1121-1124.
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Loss of the tumor suppressor SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). Rare Diseases. In press.
