Leslie J Berg
Professor
Pathology
UMass Medical School
United States of America
Biography
Leslie J Berg is professor in the department of Pathology at Umass medical School,USA.She is owner of her own research laboratory which is aimed at understanding the signal transduction pathways importantforTlymphocyte development and activation. For these studies, they use a combination of mouse genetics (transgenics and knockouts), biochemistry, and cellular immunology. Her current work focuses on three projects. First, they have identified a tyrosine kinase, Jak3, involved in cytokine receptor signaling, and have generated Jak3-deficient mice. These mice have severe defects in lymphocyte development and function. Second, they will identified a novel tyrosine kinase, Itk, involved in T cell receptor signaling. Using Itk-deficient mice generated in the lab they will currently examining the role of this protein in lymphocyte development and activation.
Research Interest
Microbes,Pathology
Publications
-
Conley JM, Gallagher MP, Berg LJ (2016) T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells. Front Immunol. 7: 76
-
Urban SL, Berg LJ, Welsh RM (2016) Type 1 interferon licenses naïve CD8 T cells to mediate anti-viral cytotoxicity. Virology. 493: 52-59.
-
arshall NB, Vong AM, Devarajan P, Brauner MD, Kuang Y, etal (2017) NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection. J Immunol. 198: 1142-1155.
