Aaron T. Smith
Assistant Professor
Chemistry and Biochemistry
UMBC
United States of America
Biography
Post-Doc, Northwestern University, 2016 M. Sc., Ph. D., University of Wisconsin—Madison, 2012 B. A., Boston University, 2007
Research Interest
Research in my lab focuses on understanding the structure and function of metalloproteins involved in crucial biological processes such as protein translation, peptide posttranslational modification, nutrient uptake, and protein regulation. My laboratory sits at the interface of chemistry, biochemistry, and biophysics, and members of my lab have the opportunity to learn a wide array of techniques from molecular biology and protein expression and purification (both soluble and membrane), to structural biology, spectroscopy, and anaerobic techniques. We welcome chemists, biochemists, and molecular biologists alike who are interested in understanding the role of inorganic elements in biological settings!
Publications
-
Smith, A. T. * ; Pazicni, S. * ; Marvin, K. A. * ; Stevens, D. J.; Freeman, K. M.; Burstyn, J. N. Functional Divergence of Heme-Thiolate Proteins: A Classification Based on Spectroscopic Attributes. Chem. Rev. 2015. 115, 2532-2558.
-
Kathman, S.; Span, I.; Smith, A. T.; Xu, Z.; Zhan, J.; Rosenzweig, A. C.; Statsyuk, A. Discovery and Structural Characterization of Covalent Inhibitors of Nedd4-1 Ubiquitin Ligase Processivity J. Am. Chem. Soc. 2015. 137, 12442-12445
-
Smith, A. T., Barupala, D., Stemmler, T. L., and Rosenzweig, A. C. Discovery and Characterization of a Novel Metal Binding Domain Involved in Cadmium, Cobalt, and Zinc Transport. Nat. Chem. Biol. 2015. 11, 678-684.
