Dan Fabris
Professor
Chemistry
University at Albany
United States of America
Biography
Professor of Chemistry and Biology Daniele Fabris is the director of the RNA MassSpec Center, part of the RNA Institute. Fabrs leads a team of researchers at UAlbany dedicated to exploring and developing the next generation of RNA-based drug therapies specifically targeting infectious diseases, such as HIV. Fabris was recently awarded a $1,768,690 grant from the National Institutes of General Medical Sciences (NIGMS) to analyze RNA-based therapeutic strategies in the treatment of HIV. Equipped with a state-of-the-art collection of instruments and enabling technologies provided through the RNA Institute's strategic partnerships, Fabris and his colleagues are embarking on projects aimed at reaching a greater understanding of the role of noncoding RNA in gene regulation and viral replication. These insights will lead to the identification of possible targets for early drug discovery that could produce alternative drugs for resistant strains of infectious diseases and new treatments for orphan diseases.
Research Interest
Using Mass spectroscopy to investigate macromolecular complexes; protein-nucleic acid interactions in viruses; high-resolution mass spectrometry; RNA-based drug therapeutics
Publications
-
Frecentese, Francesco, et al. "Synthesis and in vitro screening of new series of 2, 6-dipeptidyl-anthraquinones: influence of side chain length on HIV-1 nucleocapsid inhibitors." Journal of medicinal chemistry 59.5 (2016): 1914-1924.
-
Sosic, Alice, et al. "Direct and Topoisomerase II mediated DNA damage by Bisâ€3â€chloropiperidines: the importance of being an earnest G." ChemMedChem (2017).