Hua Shi
Associate Professor
RNA Institute
University at Albany
United States of America
Biography
Hua Shi, who joined the University in 2005, focuses his research on a forward engineering approach to cancer drug discovery and development. Shi's laboratory develops novel technology to fill the gap between “knowing” and “controlling” of normal and abnormal biological processes. Shi’s research provides a new generation of RNA based molecules with which to explore therapeutic models in living cells and organisms.
Research Interest
Molecular and cellular biology of transcription and signal transduction Aptamer-mediated multi-pathway control in living cells and organisms Drug discovery and development for cancer
Publications
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Huang, Z., Pei, W., Han, Y., Jayaseelan, S., Shekhtman, A, Shi, H., and Niu, L. (2009) One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors. Nucleic Acids Research, 37, 4022-4032.
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Mallik, P., Nishikawa, K., Millis, A., and Shi, H. (2010) Commandeering a biological pathway using aptamerÂÂderived molecular adaptors. Nucleic Acids Research, doi: 10.1093/nar/gkp1207.
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Wang, S., Shepard, J., and Shi, H. (2010) An RNA-based transcription activator derived from an inhibitory aptamer. Nucleic Acids Research, doi: 10.1093/nar/gkp1227.
