Melinda Larsen
Associate Professor
Biological Sciences
University at Albany
United States of America
Biography
Associate Professor Melinda Larsen's expertise includes organ formation and tissue engineering. Her research focuses on deciphering the molecular mechanisms controlling branching morphogenesis, a process required for the development of many mammalian organs, including the lung, kidney, prostate, mammary glands, and salivary glands. Larsen's interests also include the molecular basis for organ morphogenesis, molecular biology and cell biology.
Research Interest
Organ formation; tissue engineering, cell-cell signaling; cell-extracellular matrix signaling
Publications
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Deirdre A. Nelson, Charles Manhardt, Vidya Kamath, Yunxia Sui, Alberto Santamaria-Pang, Ali Can, Musodiq Bello, Alex Corwin, Sean Dinn, Michael Lazare, Musodiq Bello, Alex Corwin, Elise M. Gervais, Sarah B. Peters, Sharon J. Sequeira, Fiona Ginty, Michael J. Gerdes, and Melinda Larsen. 2013. Quantitative Single Cell Analysis of Cell Population Dynamics During Submandibular Salivary Gland Development and Differentiation. Biology Open. 2(5): 439-447. doi: 10.1242/bio.20134309
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Shomita S. Matthew, Bethsaida Nieves, Sharon Sequeira, Savitha Sambadamoorthy, Kevin Pumiglia, Melinda Larsen, and Susan E. Laflamme. 2014. Integrins Promote Cytokinesis Through the RSK Signaling Axis. Journal of Cell Science 127, 534-45. PMID: 24284076 doi: 10.1242/jcs.133280
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Shayoni Ray, Joseph A. Fanti, Diego P. Macedo, and Melinda Larsen. 2014. LIM Kinase Regulation of Cytoskeletal Dynamics is Required for Salivary Gland Branching Morphogenesis. Molecular Biology of the Cell. 25(16):2393-407. doi: 10.1091/mbc.E14-02-0705. PMID: 24966172
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Sarah B. Peters, Deirdre A. Nelson, Hae Ryong Kwon, Mathew Koslow, Kara A. DeSantis, and Melinda Larsen. 2015. TGFb Signaling Promotes Matrix Assembly During Mechanosensitive Salivary Gland Restoration. Matrix Biology. pii: S0945-053X(15)00034-7, doi: 10.1016/j.matbio.2015.01.020. PMID: 25652203
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Nimit Dhulekar, Shayoni Ray, Daniel Yuan, Abhirami Baskaran, Basak Oztan, Melinda Larsen, and Bülent Yener. 2016. Prediction of Growth Factor-Dependent Cleft Formation During Branching Morphogenesis Using a Dynamic Graph-Based Growth Model. IEEE IEEE/ACM Transactions on Computational Biology and Bioinformatics pp. 13, 350-364
