Paul Agris
Director
RNA Institute
University at Albany
United States of America
Biography
Professor Agris is the director of UAlbany's RNA Institute. The RNA Institute at the University at Albany leverages a new paradigm for development and delivery of innovative medicines, vaccines and diagnostics. It brings together leading researchers from higher education and other institutions, and offers advanced facilities for RNA-based drug discovery. A renowned biochemistry innovator and expert in nucleic acid design, Agris came from North Carolina State University, where he was a professor of biochemistry in the Department of Molecular and Structural Biochemistry, and, for 14 years, headed the RNA Society of North Carolina. His research insterests include RNA-based drug therapeutics, Structure/function relationships of nucleic acids, and the roles of modified nucleosides in tRNA.
Research Interest
Molecular Biology and Biophysics; structure-function relationships of nucleic acids; introduction of modified nucleosides into RNA and DNA; chemical synthesis of oligonucleotides with phosphoramidite chemistries; RNA-based drug therapeutics
Publications
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Väre, Ville YP, et al. "Chemical and Conformational Diversity of Modified Nucleosides Affects tRNA Structure and Function." Biomolecules 7.1 (2017): 29.
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Frohlich, Kyla M., et al. "Post-Transcriptional Modifications of RNA: Impact on RNA Function and Human Health." Modified Nucleic Acids in Biology and Medicine. Springer International Publishing, 2016. 91-130.
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Xiao, Xingqing, Paul F. Agris, and Carol K. Hall. "Introducing folding stability into the score function for computational design of RNAâ€binding peptides boosts the probability of success." Proteins: Structure, Function, and Bioinformatics 84.5 (2016): 700-711.
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Basanta-Sanchez, Maria, et al. "Attomole quantification and global profile of RNA modifications: Epitranscriptome of human neural stem cells." Nucleic acids research 44.3 (2016): e26-e26.
